NEW YORK, N.Y., April 20, 2026

Lirum Therapeutics, Inc. announced that new preclinical data for its investigational therapy LX-101 have been selected for presentation at the AACR Annual Meeting 2026, highlighting potent anti-tumor activity in Ewing sarcoma models and reinforcing the therapy’s potential as a next-generation targeted oncology treatment. The results demonstrate enhanced efficacy compared to earlier IGF-1R-targeting approaches, positioning LX-101 as a promising candidate in the company’s oncology pipeline.

Potent Preclinical Activity in Ewing Sarcoma

The data reveal that LX-101 delivers strong single-agent anti-tumor activity in patient-derived xenograft (PDX) models, a highly relevant preclinical system used to mimic human tumors. Ewing sarcoma, a rare and aggressive cancer affecting children and young adults, is closely associated with IGF-1R signaling pathways, making it a strategically important target for therapeutic intervention. LX-101 is a payload-bearing targeted therapy, meaning it not only binds to IGF-1R but also delivers a therapeutic payload directly to tumor cells, improving precision and potency. Compared to earlier IGF-1R inhibitors, which showed limited clinical success, LX-101 demonstrated superior tumor suppression, highlighting its potential to overcome historical limitations in this pathway.

Combination Synergy Enhances Therapeutic Potential

Beyond its standalone efficacy, LX-101 exhibited significant synergistic activity when combined with PI3K and mTOR inhibitors, resulting in enhanced anti-tumor effects across models. This suggests that LX-101 could be effectively integrated into combination treatment strategies, which are increasingly critical in oncology to address tumor complexity and resistance mechanisms. The ability to work synergistically with other targeted therapies positions LX-101 as a flexible and scalable treatment option, particularly for patients with relapsed or treatment-resistant disease. These findings support further exploration of combination regimens in future clinical trials, potentially improving outcomes in a disease with limited therapeutic advancements..

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Pipeline Advancement and Clinical Transition Strategy

Lirum Therapeutics is advancing LX-101 into clinical evaluation, supported by a “Study May Proceed” clearance from the U.S. Food and Drug Administration, enabling its inclusion in the RAPID platform clinical trial. This innovative trial design allows rapid testing of new therapies and combinations, accelerating the path from preclinical discovery to clinical validation. The inclusion of LX-101 in this platform highlights its strong translational potential and readiness for human studies. The company’s collaboration with leading research institutions further strengthens its development strategy, ensuring robust scientific and clinical evaluation.

The presentation of LX-101 at AACR 2026 underscores a significant step forward in targeted oncology innovation, particularly in addressing rare cancers like Ewing sarcoma. With its payload-based targeting mechanism, strong preclinical efficacy, and combination flexibility, LX-101 has the potential to redefine treatment approaches and improve outcomes for patients with limited options. As development progresses, the therapy will be closely watched as a next-generation candidate in precision oncology.

Source: Lirum Therapeutics press release